(P)PARsing Epidermal Development
نویسندگان
چکیده
منابع مشابه
The development of the epidermal ridges.
In man, and in his arboreal ancestors, the skin on the palmar and plantar surfaces of the hands and feet has a peculiar linear formation which is believed to help the animal to obtain a firm grip, particularly on branches of trees. The structure was first described by Nehemiah Grew, in 1684, as composed of very numerous 'ridges of equal bigness and distance and everywhere running parallel with ...
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Development of the epidermis, the outer layer of the skin formed of keratinocytes, requires the activity of the transcription factor p63, since p63-/mice are born without epidermis and consequently die at birth. The TP63 gene contains two distinct promoters, which drive the expression of two proteins, one with an amino-terminal trans-activation domain (TAp63) and one without (Np63), although t...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2006
ISSN: 0022-202X
DOI: 10.1038/sj.jid.5700137